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Updated: Aug 20, 2025

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Genetically modified malaria parasites as vaccine candidates
1Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland; University of Basel, Petersplatz 1, 4001 Basel, Switzerland.
Abstract:
Induction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated in animal models. Murphy et al. present the first, promising clinical trial of early arresting parasites, PfGAP3KO, confirming safety and demonstrating efficacy against homologous challenge.
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