Related Experiment Video

Updated: Aug 20, 2025

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.3K

Hyperoxia and Acute Kidney Injury: A Tale of Oxygen and the Kidney

Abigayle C Kraus1, Carmen De Miguel1

  • 1Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.

Seminars in Nephrology
|November 20, 2022
PubMed

Insights

Excessive oxygen therapy may harm the kidney, causing acute kidney injury. Further research is needed to understand hyperoxia

Area of Science:

  • Nephrology
  • Pulmonology
  • Critical Care Medicine

Background:

  • Oxygen supplementation is vital in clinical settings.
  • Excessive oxygen therapy (hyperoxia) is linked to lung and eye damage.
  • The impact of hyperoxia on kidney function and acute kidney injury remains unclear.

Purpose of the Study:

  • To review current understanding of hyperoxia-induced organ damage.
  • To explore potential molecular mechanisms of kidney injury from hyperoxia.
  • To identify research gaps in hyperoxia and kidney health.

Main Methods:

  • Literature review of existing studies on hyperoxia and organ damage.
  • Analysis of proposed molecular pathways.
  • Identification of areas for future research.

Main Results:

  • Hyperoxia's direct effect on kidney injury is not well understood.
  • Molecular mechanisms linking hyperoxia to kidney damage require further investigation.
  • A significant need exists for animal and clinical studies on hyperoxia and kidney damage.

Conclusions:

  • Hyperoxia may contribute to acute kidney injury.
  • Further research is crucial to elucidate mechanisms of kidney damage.
  • Optimizing oxygen therapy guidelines requires understanding its renal effects.
Keywords:
High oxygen supplementationinterorgan communicationkidneyreactive oxygen species

More Related Videos

An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury05:53

An Effective Mouse Model of Unilateral Renal Ischemia-Reperfusion Injury

Published on: July 15, 2021

7.0K
Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

2.3K

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
49
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
55
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
40
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
59
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
53
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
45