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Sleeve Gastrectomy in Mice using Surgical Clips
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Changes in circulating sirtuin 1 after bariatric surgery.

Trine B Opstad1, Per G Farup2, Helge Rootwelt3

  • 1Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, 0240 Oslo, Norway; Faculty of Medicine, University of Oslo, 0315 Oslo, Norway.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|November 21, 2022
PubMed
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Bariatric surgery significantly lowers sirtuin 1 (SIRT1) levels in obese patients. This reduction correlates with improved inflammation and triglycerides, not just weight loss, suggesting benefits for metabolic health.

Area of Science:

  • Metabolic Surgery
  • Obesity Medicine
  • Inflammation Research

Background:

  • Obesity is linked to chronic inflammation and oxidative stress, increasing cardiovascular disease risk.
  • Bariatric surgery improves inflammatory markers and cardiovascular risk in obese individuals.
  • Changes in sirtuin 1 (SIRT1) activity may underlie metabolic improvements post-surgery.

Purpose of the Study:

  • To investigate the impact of bariatric surgery on circulating sirtuin 1 (SIRT1) levels.
  • To explore the relationship between SIRT1 levels and metabolic improvements after weight loss surgery.

Main Methods:

  • Prospective cohort study of 110 morbidly obese subjects undergoing Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG).
  • Blood samples collected at baseline, 6, and 12 months post-surgery.
Keywords:
Bariatric surgeryMetaflammationObesitySirtuin1

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  • SIRT1 levels measured via enzyme-linked immunosorbent assay (ELISA); C-reactive protein (CRP) and triglycerides also assessed.

    • Main Results:

    • SIRT1 concentrations significantly decreased from baseline at 6 and 12 months post-surgery (p ≤ 0.002).
    • Significant reductions observed in C-reactive protein (CRP), body mass index (BMI), and triglycerides (p < 0.001).
    • Neither RYGB nor SG showed a differential effect on SIRT1 levels (p = 0.09); CRP and triglycerides predicted SIRT1 levels (p ≤ 0.001).

    Conclusions:

    • Bariatric surgery leads to a significant reduction in circulating SIRT1 levels.
    • The decrease in SIRT1 appears linked to improvements in metaflammation (indicated by CRP and triglycerides) rather than solely weight loss.
    • Findings suggest SIRT1 modulation is associated with improved metabolic dysfunction post-bariatric surgery.