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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
357

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Three-Dimensional Printing Technologies for Drug Delivery Applications: Processes, Materials, and Effects.

Jessica Mancilla-De-la-Cruz1, Marisela Rodriguez-Salvador1, Jia An2

  • 1Tecnologico de Monterrey, Monterrey, Nuevo Leon, Mexico.

International Journal of Bioprinting
|November 21, 2022
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Summary

Three-dimensional (3D) printing offers personalized drug delivery solutions, overcoming high costs associated with traditional manufacturing. This review comprehensively covers 3D printing processes, materials, and applications in various drug dosage forms.

Keywords:
Additive manufacturingDrug deliveryPharmaceutical applicationsThree-dimensional printing

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Area of Science:

  • Pharmaceutical Technology
  • Biomedical Engineering
  • Materials Science

Background:

  • Traditional drug delivery manufacturing requires high initial costs and bulk production.
  • Three-dimensional (3D) printing, or additive manufacturing, enables personalized drug delivery with complex geometries and multiple release profiles.
  • Existing literature lacks a comprehensive review of 3D printing processes, materials, and their effects in pharmaceutical applications.

Purpose of the Study:

  • To provide a comprehensive review of 3D printing technology for drug delivery applications.
  • To detail various 3D printing techniques, materials, and their suitability for different dosage forms.
  • To offer insights into the future directions of 3D printing in advancing drug delivery for academia and industry.

Main Methods:

  • Review of existing literature on 3D printing in pharmaceutical drug delivery.
  • Categorization of 3D printing techniques based on International Organization for Standardization (ISO) and American Society for Testing and Materials (ASTM) standards.
  • Analysis of materials (polymers, glasses, hydrogels) and dosage forms (oral, topical, implantable, etc.) utilized in 3D printed drug delivery systems.

Main Results:

  • Identified seven main categories of 3D printing: material jetting, binder jetting, material extrusion, vat photopolymerization, powder bed fusion, sheet lamination, and directed energy deposition.
  • Highlighted the use of polymers, glasses, and hydrogels as common materials in 3D printed drug delivery.
  • Discussed the application of 3D printing across various drug dosage forms, including oral, topical, rectal/vaginal, parenteral, and implantable systems.

Conclusions:

  • 3D printing technology presents a significant advancement in pharmaceutical drug delivery, enabling cost-effective, personalized solutions.
  • The review consolidates information on processes, materials, and applications, serving as a valuable resource for researchers and industry professionals.
  • 3D printing holds immense potential for innovation in drug delivery, paving the way for tailored therapeutic strategies.