QUS characteristics in Normal Population: a Mini Review and our experience
Maryam Najafi1, Minoo Najafi1, Abbas Ali Keshtkar2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Journal of Diabetes and Metabolic Disorders
|November 21, 2022
Summary
Quantitative ultrasound (QUS) provides a cost-effective, noninvasive method for bone density assessment. This study established normal QUS values for Iranian adults, showing good agreement with Western references for osteoporosis diagnosis.
Area of Science:
- Bone Densitometry
- Medical Imaging
- Osteoporosis Research
Background:
- Quantitative ultrasound (QUS) offers a portable and affordable alternative to DXA for bone densitometry.
- Key QUS parameters include speed of sound (SOS), broadband ultrasound attenuation (BUA), and stiffness index (SI).
- Establishing regional reference values is crucial for accurate diagnosis and management of bone health.
Purpose of the Study:
- To define normal quantitative ultrasound (QUS) parameter values for Iranian men and women.
- To assess the applicability of QUS for bone mass assessment in diverse populations.
- To compare Iranian QUS reference values with existing Western standards.
Main Methods:
- Heel QUS measurements were performed on 258 Iranian adults (aged 20-76) from the Iranian Multicenter Osteoporosis Study (IMOS).
- Measurements utilized an Achilles+ (GE-Lunar) device.
- Participants were selected through randomized sampling.
Main Results:
- Percentiles (2.5%, 50%, 97.5%) for stiffness index (SI) were determined for the Iranian population.
- A strong agreement (κ = 0.875) was observed between Iranian QUS-derived classifications and Western reference values for identifying normal and osteoporotic bone density.
- The study validated the use of QUS for differentiating bone mass.
Conclusions:
- Quantitative ultrasound of the heel is a viable method for diagnosing low bone mass across different geographical regions.
- The established Iranian QUS reference values facilitate accurate osteoporosis screening in the local population.
- QUS demonstrates potential as a valuable tool in global bone health initiatives.
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