Natural products and drug discovery
1NIH Special Volunteer, Wayne, PA 19087, USA.
National Science Review
|November 21, 2022
Summary
This review highlights natural products and derivatives for anti-infectives, cancer treatments like antibody drug conjugates, type 2 diabetes (T2DM) drugs, and angiotensin converting enzyme inhibitors, detailing their recent history and structures.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Natural Products Chemistry
Background:
- Natural products and their derivatives are crucial in drug discovery.
- Recent advancements have expanded their therapeutic applications.
- This review focuses on key therapeutic areas where these compounds are vital.
Purpose of the Study:
- To provide a historical overview of significant natural products and derivatives.
- To discuss their current applications and ongoing evaluations in medicine.
- To present the chemical structures of these important agents.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of drug development pipelines and clinical evaluations.
- Compilation and presentation of chemical structures.
Main Results:
- Identification of key natural products and derivatives in anti-infective and oncology fields.
- Overview of their roles in managing type 2 diabetes (T2DM) and hypertension.
- Detailed structural information for evaluated agents, including peptide abbreviations.
Conclusions:
- Natural products remain a cornerstone of modern pharmacotherapy.
- Ongoing research continues to yield novel derivatives with significant therapeutic potential.
- This review synthesizes critical information for researchers and clinicians in these fields.
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