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Updated: Aug 20, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
The Use of Deep Snare Biopsies to Diagnose Cronkhite-Canada Syndrome
Natalia Filipek1,2, Peter Dromparis3, Isabel A Hujoel1
1Department of Gastroenterology, University of Washington, Seattle, WA.
Abstract:
Cronkhite-Canada syndrome is a rare sporadic polyposis syndrome that presents with dermatologic and neurologic symptoms in addition to nutritional deficiencies. It can mimic alternate pathologies, such as Menetrier disease, making adequate histologic sampling with deep snare biopsies necessary for tissue comparison. We present a case report of Cronkhite-Canada syndrome that demonstrates the importance of deep tissue sampling for adequate diagnosis and treatment initiation.
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