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Minimal change disease caused by polycythemia vera: A case report
Li Xu1, Li-Li Lu1, Jian-Dong Gao2
1Department of Nephrology, Shuguang Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (20DZ2272200), Shanghai 201203, China.
Polycythemia vera (PV), a blood disorder, may be linked to minimal change disease, a rare kidney condition. This case study suggests a potential causal relationship, offering new insights for both conditions.
Area of Science:
- Nephrology
- Hematology
- Oncology
Background:
- Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by elevated red blood cell counts, often due to the JAK2 V617F mutation.
- While PV can be associated with renal complications, PV-associated minimal change disease (MCD) has not been previously reported.
Observation:
- A 37-year-old male presented with proteinuria and erythrocytosis.
- Diagnostic workup, including bone marrow and renal biopsies, confirmed concurrent diagnoses of PV and MCD.
Findings:
- Treatment with hydroxyurea led to remission of proteinuria in the patient.
- This case presents the first reported instance of minimal change disease in a patient with Polycythemia vera.
Implications:
- The findings suggest a potential causal link between Polycythemia vera and minimal change disease.
- Further research is warranted to elucidate the underlying mechanisms connecting these two conditions and inform clinical management.
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