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Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Special Features of Adaptive Immunity

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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
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Related Experiment Video

Updated: Aug 20, 2025

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Autoimmunity: Are we asking the right question?

Polly Matzinger¹

¹Ghost Lab, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States.

Frontiers in Immunology

|November 21, 2022

Summary

This summary is machine-generated.

Autoimmune diseases may stem from faulty tissue function, not a loss of self-tolerance. This research reframes the central question in autoimmunity, suggesting new avenues for understanding these complex conditions.

Keywords:

T helper cells (Th cells)autoimmunity autoreactivity pregnancy programmed cell death, danger model tissue resident cells tissue-based class control

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Last Updated: Aug 20, 2025

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Area of Science:

Immunology
Pathophysiology
Autoimmune Diseases

Background:

The central question in immunology has long been the cause of self-tolerance breakdown in autoimmunity.
Despite decades of research, a definitive answer remains elusive, prompting a re-evaluation of the fundamental question.

Purpose of the Study:

To propose an alternative hypothesis for the etiology of autoimmune diseases.
To shift the focus from a "break in self-tolerance" to potential defects in normal tissue physiology.

Main Methods:

Conceptual review and hypothesis generation.
Analysis of existing immunological and physiological data.

Main Results:

The traditional focus on "break in self-tolerance" may be an unproductive paradigm.
Defects in normal tissue physiology present a plausible alternative or contributing factor to autoimmune diseases.

Conclusions:

Re-framing the core question in autoimmunity research is crucial for progress.
Investigating tissue physiology defects offers a promising new direction for understanding and potentially treating autoimmune conditions.