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The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
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Single-atom nanozymes: From bench to bedside.

Chanyuan Jin1, Sanjun Fan2, Zechao Zhuang3

  • 1Second Dental Center, Peking University School and Hospital of Stomatology, Beijing, 100101 China.

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Summary
This summary is machine-generated.

Single-atom nanozymes (SANs) offer enzyme-like catalytic activity with high efficiency and low cost. Recent research highlights their potential in diverse medical applications, including cancer therapy and biosensing.

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anti-infective treatmentantioxidative therapybiosensingcancer therapysingle-atom nanozymes

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Catalysis

Background:

  • Single-atom nanozymes (SANs) are advanced nanomaterials mimicking natural enzymes.
  • They possess unique advantages like high atom utilization, catalytic efficiency, and selectivity.
  • SANs are increasingly explored for biological and medical applications.

Purpose of the Study:

  • To review recent advancements in single-atom nanozymes for medical applications.
  • To highlight the potential of SANs in anti-infective, anti-cancer, biosensing, and antioxidative therapies.
  • To provide insights into the future clinical prospects of SANs in medicine.

Main Methods:

  • Literature review of recent studies on single-atom nanozymes in biological contexts.
  • Analysis of research focusing on SANs for anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
  • Synthesis of findings to illustrate current capabilities and future directions.

Main Results:

  • SANs demonstrate significant promise in anti-infective treatments.
  • They show potential in cancer diagnosis and therapy, offering targeted treatment strategies.
  • SANs are effective in biosensing applications and show promise in antioxidative therapies.

Conclusions:

  • Single-atom nanozymes represent a rapidly developing field with substantial potential in clinical medicine.
  • Further research is warranted to translate these promising findings into practical therapeutic and diagnostic tools.
  • SANs are poised to become valuable agents in future medical interventions.