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Updated: Aug 20, 2025

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Evolutionary genetics of malaria.

Kristan Alexander Schneider¹, Carola Janette Salas²

¹Department of Applied Computer- and Biosciences, University of Applied Sciences Mittweida, Mittweida, Germany.

Frontiers in Genetics

|November 21, 2022

Summary

This summary is machine-generated.

Malaria parasite evolution is complex due to distinct species and dormant stages. Our new population-genetic model accounts for these factors, showing they delay drug resistance spread and decouple selection from recombination.

Keywords:

co-infection complexity of infection (COI)hypnozoites mixed-species infection multiplicity of infection (MOI)recrudescence relapse seed bank

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Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Area of Science:

Population Genetics
Infectious Disease Dynamics
Parasitology

Background:

Malaria is a major global health issue caused by five human-pathogenic Plasmodium species.
Standard population-genetic models often fail to capture the unique biological features of malaria parasites.
Distinct parasite life-histories, including dormant stages, significantly impact disease evolution and control.

Purpose of the Study:

To develop and extend a population-genetic framework applicable to all human-pathogenic malaria species.
To investigate how parasite-specific features, such as dormant stages, influence evolutionary dynamics, particularly drug resistance.
To analyze the interplay between haplotype frequencies, transmission, and disease relapses/recrudescence.

Main Methods:

Development of an extended population-genetic model for malaria evolutionary dynamics.
Analysis of how dormant parasite stages (hypnozoites, inactivated blood-stage parasites) affect evolutionary processes.
Examination of the decoupling of selection and recombination in malaria parasite evolution.

Main Results:

The proposed framework accurately models evolutionary processes across different human-pathogenic malaria species.
Dormant parasite stages act as "seed banks," significantly delaying the spread of anti-malarial drug resistance.
Contrary to standard theory, selection and recombination processes cannot be decoupled in malaria evolution.

Conclusions:

A tailored population-genetic approach is essential for understanding malaria evolution.
Parasite dormancy plays a critical role in the tempo of evolutionary change, impacting drug resistance.
The study highlights the complex relationship between parasite biology, population genetics, and malaria control strategies.