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Updated: Aug 20, 2025

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
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Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

Sharun Kuhar1, Jae Ho Lee, Jung-Hee Seo

  • 1Department of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.

Physics of Fluids (Woodbury, N.Y. : 1994)
|November 21, 2022
PubMed

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Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
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Gastric emptying occurs when the stomach gradually releases chyme into the duodenum. When the stomach is distended, it triggers the release of gastrin, a hormone that promotes gastric acid secretion to aid in digestion. Additionally, stomach distension contributes to peristaltic waves that propel gastric contents toward the pyloric region. The gastroenteric reflex, on the other hand, primarily stimulates peristalsis in the intestines, facilitating the movement of contents further along the...
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