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Mapping current research and identifying hotspots of ferroptosis in cardiovascular diseases
Teng Teng1,2, Chun-Yan Kong1,2, Rong Huang1,2
1Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Insights
Ferroptosis, a cell death linked to iron metabolism, is increasingly studied in cardiovascular diseases (CVDs). Research highlights ischemia-reperfusion injury, heart failure, and atherosclerosis as key areas, with future focus on endothelial injury and gut microbiota.
Area of Science:
- Biomedical research focusing on cell death mechanisms and cardiovascular pathology.
- Investigates ferroptosis, a distinct iron-dependent cell death pathway, and its implications in cardiovascular diseases (CVDs).
Background:
- Ferroptosis, characterized by iron metabolism disruption, differs from apoptosis and is implicated in various cardiovascular diseases.
- A bibliometric analysis was needed to comprehensively summarize the growing body of research on ferroptosis in CVDs.
Approach:
- Bibliometric analysis of 263 studies retrieved from the Web of Science Core Collection database.
- Utilized VOSviewer and Citespace for statistical and visualization analysis of the literature.
- Examined publication trends, leading countries, institutions, authors, and research hotspots.
Key Points:
- Research on ferroptosis in CVDs shows a consistent upward trend, with China as the most productive country.
- Ischemia-reperfusion (I/R) injury, heart failure (HF), and atherosclerosis are the primary research directions.
- Limited international collaboration was observed, suggesting a need for enhanced scientific communication.
Conclusions:
- The study provides a comprehensive overview of influential research on ferroptosis in CVDs, particularly noting significant interest from China.
- Future research should explore the roles of endothelial injury and gut microbiota in ferroptosis-related cardiovascular conditions.
- Increased international cooperation is recommended to advance the field.
Objective:
Ferroptosis is a unique cell death depended on iron metabolism disorder which is different from previous apoptosis-regulated cell death. Early studies have proposed that ferroptosis is closely associated with multiple cardiovascular diseases (CVDs). However, the relationship of ferroptosis and CVDs has not been summarized by using bibliometric analysis. We intended to illustrate the development of ferroptosis in CVDs over the past years and provide relevant valuable information.
Materials And Methods:
The authoritative database of Web of Science Core Collection was collected for retrieving ferroptosis studies in CVDs. In this work, statistical and visualization analysis were conducted using VOSviewer and Citespace.
Results:
A total of 263 studies were included in the final study. From the perspective of the overall literature, the study maintains an increased trend year by year and most manuscripts belonged to original article. China was the most productive country with the utmost scientific research output, as well as the institutions and authors, followed by Germany and the United States of America (USA). Jun Peng from China contributes to the most publications. Collaborative efforts between institutes and authors were limited and there was little widespread cooperation. In addition, burst keywords analysis discovered that ischemia-reperfusion (I/R) injury, heart failure (HF), and atherosclerosis were the top three research directions of ferroptosis in CVDs. The burst investigation and timeline views also indicated that endothelial injury and gut microbiota may also serve as new research topics in the future.
Conclusion:
This study provided comprehensive and specific information about the most influential articles on ferroptosis in CVDs. The relationship between ferroptosis and CVDs had attracted the scholar's concerns especially in China. Cooperations and communications between countries and institutions should be emphasized and future directions can be concentrated on endothelial disorder and gut microbiota.
