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ENhANCE trial protocol: A multi-centre, randomised, phase IV trial comparing the efficacy of oxycodone/naloxone

Aaron K Wong1,2,3, Anneke Grobler4,5, Brian Le1,2

  • 1Department of Palliative Care Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, 3000, Australia.

Contemporary Clinical Trials Communications
|November 21, 2022
PubMed
Abstract

Keywords:
AnalgesicsBFI, Bowel Function IndexBPI – SF, Brief Pain Inventory – Short FormCKD-EPI, Chronic Kidney Disease Epidemiology Collaboration calculationConstipationEORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life QuestionnaireGEE, Generalised Estimating EquationsITT, Intention To TreatNeoplasmsOIC, opioid-induced constipationOXN PR, oxycodone/naloxone prolonged releaseOpioidOxy PR, oxycodone prolonged releasePRO CoMiDa, Patient Reported Outcome Completion and Missing Data ChecklistPRO, Patient Reported OutcomePainPalliative careS-LANSS, Leeds Assessment of Neuropathic Symptoms & Signs

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