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Updated: Aug 20, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Extending artificial intelligence research in the clinical domain: a theoretical perspective
Renu Sabharwal1, Shah J Miah1, Samuel Fosso Wamba2
1Newcastle Business School, The University of Newcastle, Callaghan, NSW Australia.
This systematic review explores artificial intelligence (AI) applications in clinical care, identifying key areas and future research directions for machine learning to enhance patient outcomes and disease management.
Area of Science:
- * Medical Informatics
- * Artificial Intelligence in Healthcare
Background:
- * Rapid advancements in artificial intelligence (AI) and machine learning (ML) have transformed various sectors, yet their integration into daily clinical practice remains underexplored.
- * A significant gap exists in understanding the current landscape and potential of AI/ML for improving patient care and disease management.
Purpose of the Study:
- * To systematically review and map the applications of AI and ML in clinical care.
- * To identify strategies, algorithms, and outcomes associated with AI implementation in healthcare settings.
- * To provide insights into future research directions and the influence of AI on disease management.
Main Methods:
- * A systematic literature review employing a smart approach.
- * Latent Dirichlet Allocation (LDA) topic modeling used to analyze and categorize 305 unique articles, with 115 selected for inclusion.
- * Focus on strategies, algorithms, applications, results, qualities, and implications of AI in the clinical domain.
Main Results:
- * Identified key application areas of AI and ML in clinical care and disease management.
- * Provided a structured overview of current AI strategies, algorithms, and their reported outcomes.
- * Highlighted the potential of AI to influence future healthcare practices and patient care.
Conclusions:
- * AI technologies offer significant potential to enhance patient care and disease management within clinical settings.
- * Further research is needed to fully realize the capabilities and implications of AI in healthcare.
- * The study outlines future research directions, limitations, and administrative ramifications of AI in clinical practice.
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