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Commentary: Predicting blood concentration of tacrolimus in patients with autoimmune diseases using machine learning

Yuxiang Zhu1, Xuebin Wang2, Xue Wang2

  • 1Shanghai Altimetria Cloudlink Healthcare Technology Co., Ltd., Shanghai, China.

Frontiers in Pharmacology
|November 21, 2022
PubMed
Abstract

No abstract available in PubMed .

Keywords:
XGBoost, extreme gradient boostingblood concentration predictionmachine learningtacrolimustherapeutic drug monitoring

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.