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Related Concept Videos

Toxic Reactions: Overview01:26

Toxic Reactions: Overview

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Types of Toxins01:36

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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
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Effects of Chemicals: Overview01:27

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Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
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EDTA: Auxiliary Complexing Reagents01:26

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EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
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Related Experiment Video

Updated: Aug 20, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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Data curation to support toxicity assessments using the Integrated Chemical Environment.

Amber B Daniel1, Neepa Choksi1, Jaleh Abedini1

  • 1Inotiv, Research Triangle Park, NC, United States.

Frontiers in Toxicology
|November 21, 2022
PubMed
Summary
This summary is machine-generated.

The Integrated Chemical Environment (ICE) streamlines toxicity data integration for New Approach Methodologies (NAMs). Rigorous data curation ensures reliable chemical assessments, supporting safer chemical development and reducing animal testing.

Keywords:
FAIRdata curationdata harmonizationnon-animal methodstoxicology

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Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Computational Biology

Background:

  • Chemical exposure poses risks, necessitating reliable toxicity data for health impact assessment.
  • New Approach Methodologies (NAMs) require diverse, integrated chemical data for development and evaluation.
  • Data integration challenges arise from varied study formats and missing metadata.

Purpose of the Study:

  • To describe the data curation workflow for the Integrated Chemical Environment (ICE).
  • To facilitate the development, evaluation, and application of NAMs through improved data accessibility.
  • To enhance knowledge discovery and interoperability in chemical toxicity assessment.

Main Methods:

  • Development of the Integrated Chemical Environment (ICE) platform.
  • Implementation of rigorous data harmonization, standardization, and formatting.
  • Utilizing both automated and manual expert-driven data curation approaches.

Main Results:

  • ICE provides curated toxicity data and computational tools for data integration and exploration.
  • The data curation workflow ensures data utility, integrity, and context preservation.
  • Facilitated application of data within ICE and external workflows.

Conclusions:

  • ICE data curation enhances the structure, reliability, and accessibility of toxicity data.
  • The developed workflow supports robust chemical assessments and the advancement of NAMs.
  • Improved data integration is crucial for efficient and ethical chemical safety evaluations.