Data curation to support toxicity assessments using the Integrated Chemical Environment.

Area of Science:

• Environmental Health Sciences
• Toxicology
• Computational Biology

Background:

• Chemical exposure poses risks, necessitating reliable toxicity data for health impact assessment.
• New Approach Methodologies (NAMs) require diverse, integrated chemical data for development and evaluation.
• Data integration challenges arise from varied study formats and missing metadata.

Purpose of the Study:

• To describe the data curation workflow for the Integrated Chemical Environment (ICE).
• To facilitate the development, evaluation, and application of NAMs through improved data accessibility.
• To enhance knowledge discovery and interoperability in chemical toxicity assessment.

Main Methods:

• Development of the Integrated Chemical Environment (ICE) platform.
• Implementation of rigorous data harmonization, standardization, and formatting.
• Utilizing both automated and manual expert-driven data curation approaches.

Main Results:

• ICE provides curated toxicity data and computational tools for data integration and exploration.
• The data curation workflow ensures data utility, integrity, and context preservation.
• Facilitated application of data within ICE and external workflows.

Conclusions:

• ICE data curation enhances the structure, reliability, and accessibility of toxicity data.
• The developed workflow supports robust chemical assessments and the advancement of NAMs.
• Improved data integration is crucial for efficient and ethical chemical safety evaluations.