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The association of arterial stiffness index with cerebrovascular and cardiometabolic disease: A Mendelian

Weishi Liu1,2,3, Luyang Zhang1,2, Yuan Gao1,2

  • 1Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

International Journal of Stroke : Official Journal of the International Stroke Society
|November 21, 2022
PubMed

Insights

Arterial stiffness index (ASI) may increase the risk of ischemic stroke (IS). This Mendelian randomization study found a link between genetically predicted ASI and higher IS risk, particularly large artery atherosclerosis stroke.

Area of Science:

  • Cardiovascular epidemiology
  • Genetics
  • Neurology

Background:

  • Arterial stiffness index (ASI) is a potential risk factor for cerebrovascular and cardiometabolic diseases.
  • Causal links between ASI and these diseases remain inconclusive.

Purpose of the Study:

  • To evaluate the causal effects of ASI on cerebrovascular and cardiometabolic diseases using Mendelian randomization (MR).

Main Methods:

  • Two-sample MR analysis utilizing genetic variants associated with ASI.
  • Inverse variance weighted method for effect estimation.
  • Sensitivity analyses to assess heterogeneity and pleiotropy.

Main Results:

  • Genetically predicted ASI showed a significant association with an increased risk of all-cause ischemic stroke (IS) (OR = 1.894, p = 0.005).
  • A suggestive association was observed between genetically predicted ASI and large artery atherosclerosis stroke (LAS) (OR = 3.726, p = 0.020).
  • No significant links were found between ASI and other cerebrovascular or cardiometabolic diseases, or specific IS etiologies like cardioembolism or small vessel occlusion.

Conclusions:

  • Genetically predicted ASI is associated with an elevated risk of ischemic stroke.
  • Further research is needed to elucidate the underlying pathways and mechanisms connecting ASI and IS.
Abstract

Keywords:
Arterial stiffness indexcardiometabolic diseasecerebrovascular diseaseischemic strokelarge artery atherosclerosis

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