Effects of hypertension and aging on brain function in spontaneously hypertensive rats: a longitudinal resting-state...

To investigate the dynamic evolution of brain function under the comorbidities of hypertension and aging. Resting-state functional magnetic resonance imaging scans were longitudinally acquired at 10, 24, and 52 weeks in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats. We computed the mean amplitude of low-frequency fluctuation (mALFF), mean regional homogeneity (mReHo), and functional connectivity (FC). There was no interaction between hypertension and aging on brain function. The main effect of aging reflects primarily the cumulative increase of brain activity, especially the increase of mALFF in amygdala and mReHo in cingulate cortex, accompanied by the decrease of brain activity. The main effect of hypertension reflects primarily decreased brain activity in default modal network, accompanied by increased brain activity. The main effect of aging shows reduced brain FC as early as 24 weeks, and the main effect of hypertension shows higher brain FC in SHRs. The novel discovery is that 1 brain FC network increased linearly with age in SHRs, in addition to the linearly decreasing FC. Hypertension and aging independently contribute to spatiotemporal alterations in brain function in SHRs following ongoing progression and compensation. This study provides new insight into the dynamic characteristics of brain function.