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Updated: Jun 23, 2026

Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study
Published on: January 31, 2014
Discussion on: Instrumented difference-in-differences, by Ting Ye, Ashkan Ertefaie, James Flory, Sean Hennessy and
1Department of Statistical Science, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Abstract:
I discuss the assumptions needed for identification of average treatment effects and local average treatment effects in instrumented difference-in-differences (IDID), and the possible trade-offs between assumptions of standard IV and those needed for the new proposal IDID, in one- and two-sample settings. I also discuss the interpretation of the estimands identified under monotonicity. I conclude by suggesting possible extensions to the estimation method, by outlining a strategy to use data-adaptive estimation of the nuisance parameters, based on recent developments.
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