Selective turn-on fluorescence sensing of Fe²⁺ in real water samples by chalcones

The design of fluorescence sensor for selective detection of Fe²⁺ is very important as it is part of different biochemical redox system related to a number of diseases. In many occasion sensors are unable to distinguish Fe²⁺ from Fe³⁺ ions. In the present work, we report simple chalcone type sensors for sensing Fe²⁺ ions in semi aqueous system. The receptors R1 and R2 have showed excellent sensing properties at pH 7 in CH₃OH-H₂O (1:1, v/v) solvent system. The fluorescence emission intensity of the complexes between hosts and Fe²⁺ is least affected by the other competitive metal ions leading to the formation of very tight host-guest complex. The LOD for the R1 and R2 for Fe²⁺ are 1.91 μM and 3.54 μM respectively, which is quite low in compared to the many other reported sensors. The practical applicability of these sensors is determined by the detection of Fe²⁺ in real water samples. So chalcones would be cost effective PET inhibited fluorescence sensor for Fe²⁺.