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Updated: Aug 20, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Anabolic-androgenic steroid abuse and testicular function in men; recent insights
Willem de Ronde1, Diederik L Smit2
1Department of Internal Medicine, Spaarne Gasthuis, PO BOX 417, 2000 AK, Haarlem, the Netherlands; Department of Internal Medicine, Elizabeth-Tweesteden Ziekenhuis, Tilburg, the Netherlands.
Abstract:
The use of illegal androgens by young men is not uncommon. The majority of users take multiple courses of androgens during their lifetime, leading to a high cumulative exposure. An inseparable side effect is suppression of gonadal function. Although this usually recovers, recovery can take a long time and is not without symptoms. This review focusses on recent studies that have greatly increased our knowledge of the disruption and recovery of testicular function during and after androgen abuse. For the guidance and treatment of (potential) users, in-depth knowledge of this is indispensable.
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