Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kubler Ross's Stages of Dying01:21

Kubler Ross's Stages of Dying

245
Elisabeth Kübler-Ross significantly advanced psychology's understanding of the process of dying with her influential book, On Death and Dying (1969). She focused on studying terminally ill individuals and outlined five stages commonly experienced when coping with death: denial, anger, bargaining, depression, and acceptance.
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
245
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

37
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
37
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

425
The pathophysiology of pneumonia involves the following steps:
425
Acute Respiratory Failure-IV01:23

Acute Respiratory Failure-IV

189
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
189
Stages of Infection01:26

Stages of Infection

58.3K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
58.3K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advance care planning in the last year of life of patients with advanced cancer: patients' perspectives on decision-making and their family and physicians' awareness of future care preferences.

Journal of cancer survivorship : research and practice·2026
Same author

Supporting the Integration of the Existential Dimension Into Clinical Practice: Health Care Providers' Experiences With a Meaning-Making Synopsis of Patients Living Long-Term With Incurable Cancer.

Psycho-oncology·2026
Same author

Improving the Understanding of Late Effects of Testicular Cancer in Adolescent and Young Adult Survivors: TRANSCEND-XR.

Andrology·2026
Same author

End-of-life decision-making: A cross-sectional study on knowledge and views of the Dutch general public.

Death studies·2026
Same author

Experiences with an Advance Care Planning Intervention for Children with Life-Limiting Conditions: A Qualitative Study of Families and Clinicians Using the IMplementing Pediatric Advance Care Planning Toolkit.

Children (Basel, Switzerland)·2026
Same author

A Meaning-Making Conversation: A Formative Mixed Method Pilot Study of a Brief Intervention for Patients Living Long-Term With Incurable Cancer.

The American journal of hospice & palliative care·2026

Related Experiment Video

Updated: Aug 20, 2025

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.8K

Symptom evolution in the dying.

Madelon T Heijltjes1, Lia van Zuylen2, Ghislaine Jmw van Thiel3

  • 1Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands m.t.heijltjes-2@umcutrecht.nl.

BMJ Supportive & Palliative Care
|November 21, 2022
PubMed
Summary

Symptom management for dying patients is not always optimal, with many experiencing unmet care goals for pain and restlessness. Further research and systematic assessment are crucial for improving end-of-life care.

Keywords:
End of life careTerminal care

More Related Videos

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
10:29

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Published on: March 16, 2020

8.0K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.7K

Related Experiment Videos

Last Updated: Aug 20, 2025

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
06:49

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

Published on: October 6, 2015

19.8K
Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
10:29

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

Published on: March 16, 2020

8.0K
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.7K

Area of Science:

  • Palliative Care
  • Symptom Management
  • End-of-Life Care

Background:

  • Effective symptom management is crucial for patients nearing the end of life.
  • Understanding the prevalence of unmet symptom-related care goals is essential for improving palliative care.

Purpose of the Study:

  • To investigate the prevalence of unmet symptom-related care goals in patients in the final days of life.
  • To identify specific symptoms that are frequently not adequately managed.

Main Methods:

  • Retrospective analysis of data from 2786 patients across 20 Dutch healthcare facilities (2012-2019).
  • Data extracted from 4-hourly registrations in the Care Programme for the Dying Person.
  • Analysis focused on the initial and final 4-hour periods relative to the start of the care program and death.

Main Results:

  • Between 28.5% and 42.8% of patients had at least one unmet symptom-related care goal in the first 4 hours.
  • In the last 4 hours before death, 17.5% to 26.9% of patients experienced unmet goals.
  • Pain (7.3%-20.9%) and restlessness (9.3%-21.9%) were the most common unmet care goals.

Conclusions:

  • Symptom control for patients at the end of life is suboptimal for a significant number of individuals.
  • Systematic assessment, focused attention, and further research into symptom management are necessary to enhance end-of-life care.