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Related Experiment Video

Updated: Aug 20, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Longitudinal Changes in Upper and Lower Airway Function in Pregnancy.

Vanessa E Murphy1, Megan E Jensen1

  • 1Priority Research Centre for Healthy Lungs, University of Newcastle, Newcastle, New South Wales, Australia; Hunter Medical Research Institute, Level 2 West, c/- University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia.

Immunology and Allergy Clinics of North America
|November 21, 2022
PubMed
Summary

Pregnancy causes airway changes, increasing resistance and decreasing lung capacity. Spirometry remains a valuable tool for assessing asthma during pregnancy, as lung function changes are minimal.

Keywords:
AsthmaLung functionPulmonary function testsRhinitisSleep-disordered breathingSpirometry

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Area of Science:

  • Obstetrics and Gynecology
  • Pulmonology
  • Respiratory Physiology

Background:

  • Physiologic changes during pregnancy impact respiratory function.
  • Increased upper airway resistance and decreased total lung capacity are observed.
  • Pregnancy can exacerbate upper airway symptoms, rhinitis, and sleep-disordered breathing.

Purpose of the Study:

  • To review the impact of pregnancy on upper and lower airway function.
  • To assess the clinical significance of these changes, particularly in women with asthma.
  • To determine the utility of spirometry for managing asthma during pregnancy.

Main Methods:

  • Review of longitudinal studies and existing literature on respiratory function during pregnancy.
  • Analysis of changes in upper and lower airway parameters.
  • Evaluation of spirometry's role in clinical assessment.

Main Results:

  • Pregnancy is associated with increased upper airway resistance and decreased total lung capacity.
  • Prevalence of sleep-disordered breathing and pregnancy-induced rhinitis increases.
  • Observed reductions in lung function with gestation are generally small and not clinically significant.

Conclusions:

  • Physiologic changes during pregnancy affect airway function, but lung function decline is minimal.
  • Spirometry is a reliable and clinically significant tool for assessing women with asthma throughout pregnancy.
  • Further longitudinal studies are needed, especially in asthmatic populations.