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Related Experiment Video

Updated: Aug 20, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

Globular glial tauopathy type II.

Patrick W Cullinane^1,2, Katie Sidle³, Kailash P Bhatia¹

¹Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.

Practical Neurology

|November 21, 2022

Summary

This summary is machine-generated.

Globular glial tauopathies (GGTs) are rare neurodegenerative diseases. A recent case confirms GGT type II as a distinct entity, aiding potential anti-tau therapy development.

Keywords:

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Area of Science:

Neuroscience
Neuropathology
Rare Diseases

Background:

Globular glial tauopathies (GGTs) represent a rare class of neurodegenerative disorders.
Recent research, focusing on tau filament structures, has solidified GGT as a distinct neuropathological entity, separate from progressive supranuclear palsy.

Observation:

This study details a sporadic case of GGT type II in a 74-year-old woman.
The patient presented with an overlap syndrome of progressive corticobasal and primary lateral sclerosis.
Neuropathological analysis revealed characteristic neuronal and glial tau inclusions, including globular astrocytic and oligodendroglial types.

Findings:

The case presented supports the classification of GGT as a unique neuropathological entity.
The molecular pathophysiology and clinical manifestations of GGT were further elucidated.

Implications:

Increased recognition of GGT is crucial for patient identification.
Patients with GGT may be eligible for emerging anti-tau therapies currently in clinical trials for other tauopathies.