Related Experiment Video

Updated: Aug 20, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Correlation between serum Dickkopf-1 (DKK1) levels and coronary artery stenosis

Hongxiu Xu1, Zhenjiang Ding2, Jiaoyue Chen3

  • 1Development of Endocrinology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, PR China; The First Hospital of Qinghuangdao, PR China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|November 21, 2022
PubMed

Insights

Serum Dickkopf-1 (DKK1) levels are higher in patients with coronary heart disease (CHD) and correlate with stenosis severity. DKK1 is an independent risk factor for CHD.

Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Research

Background:

  • Coronary atherosclerotic heart disease (CHD) poses a significant health burden.
  • Understanding biomarkers for CHD severity is crucial for patient management.
  • Dickkopf-1 (DKK1) has emerged as a potential factor in cardiovascular disease.

Purpose of the Study:

  • To investigate the correlation between serum Dickkopf-1 (DKK1) levels and the degree of coronary artery stenosis.
  • To assess DKK1 as a potential biomarker for coronary atherosclerotic heart disease.

Main Methods:

  • A cohort of 311 patients undergoing coronary angiography were analyzed.
  • Serum concentrations of DKK1, RBP4, and PAI-1 were measured.
  • Patients were categorized into non-CHD and CHD groups, with the latter further stratified by Gensini score.

Main Results:

  • Serum DKK1, RBP4, and PAI-1 levels were significantly elevated in the CHD group compared to the non-CHD group.
  • Higher DKK1, RBP4, and PAI-1 levels were observed in patients with moderate to severe coronary artery stenosis (higher Gensini scores).
  • Serum DKK1 showed a positive correlation with inflammatory markers RBP4 and PAI-1.

Conclusions:

  • Elevated serum DKK1 levels are associated with coronary heart disease and correlate with the severity of coronary artery stenosis.
  • DKK1 is identified as an independent risk factor for coronary heart disease.
  • DKK1 may serve as a valuable biomarker for assessing CHD risk and severity.
Abstract

Keywords:
Coronary artery stenosisCoronary atherosclerotic heart diseaseDKK1Dickkopf-1

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.1K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.2K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
46
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
139
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
56
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
23
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
20
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
25