Related Experiment Video

Updated: Aug 20, 2025

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis
08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

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A Glimpse of necroptosis and diseases

Ming Yang1, Wei Chen2, Liyu He2

  • 1Department of Nutrition, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China; Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|November 22, 2022
PubMed

Insights

Necroptosis, a programmed cell death pathway involving RIPK1, RIPK3, and MLKL, can cause inflammation and disease when abnormally activated. Targeting necroptosis offers a promising therapeutic strategy for various conditions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Immunology

Background:

  • Programmed cell death is crucial for maintaining bodily homeostasis.
  • Necroptosis is a recently identified form of programmed cell death.
  • Dysregulated necroptosis is implicated in inflammatory diseases.

Purpose of the Study:

  • To review the molecular mechanisms of necroptosis.
  • To discuss necroptosis's role in disease pathogenesis.
  • To explore necroptosis inhibitors as potential therapeutics.

Main Methods:

  • Literature review of necroptosis.
  • Analysis of molecular pathways (RIPK1, RIPK3, MLKL).
  • Review of disease associations and therapeutic strategies.

Main Results:

  • Necroptosis is a regulated necrotic cell death pathway.
  • Abnormal necroptosis activation contributes to inflammation and disease.
  • Several necroptosis inhibitors are under development.

Conclusions:

  • Understanding necroptosis mechanisms is key to disease intervention.
  • Targeting necroptosis presents a viable therapeutic avenue.
  • Further research into necroptosis inhibitors is warranted.
Keywords:
InflammationMLKLNecroptosisProgrammed cell deathRIPK1

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