Zebrafish as model for studies in dentistry

Area of Science:

• Comparative Biology
• Biomedical Research
• Dental Science

Background:

• Zebrafish (Danio rerio) have emerged as a prominent vertebrate animal model in biomedical research.
• Their utility spans toxicology, developmental biology, and increasingly, dental research applications.

Purpose of the Study:

• To conduct a comprehensive literature review on the application of zebrafish in dentistry.
• To evaluate the viability of zebrafish as an alternative animal model for dental research.

Main Methods:

• A systematic literature search was conducted across major databases: PubMed, Lilacs, Embase, and Dentistry and Oral Sciences Source.
• Keywords included 'zebrafish' and 'dentistry'.
• Inclusion criteria focused on English-language articles utilizing zebrafish in dentistry, oral health, and craniofacial development studies.

Main Results:

• The initial search yielded 421 articles.
• Following abstract analysis, 29 articles were selected for full-text review.
• These selected studies demonstrated the application of zebrafish in diverse dental research areas.

Conclusions:

• The reviewed literature confirms the zebrafish's suitability as an animal model for various dental studies.
• Zebrafish research effectively complements and assists studies involving mammalian models in dentistry.
• This model offers a valuable alternative for investigating oral health and craniofacial development.