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Nanozymes in the Treatment of Diseases Caused by Excessive Reactive Oxygen Specie

Shufeng Liang1,2, Xin Tian3, Chunyan Wang4

  • 1Department of Molecular Biology, Shanxi Province Cancer Hospital/Shanxi Hospital, Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, People's Republic of China.

Journal of Inflammation Research
|November 22, 2022
PubMed

Insights

Nanozymes, nanomaterials with enzyme-like antioxidant properties, offer promising therapeutic potential for diseases linked to excessive reactive oxygen species (ROS). Strategies to modulate nanozyme activity are key for treating ROS-induced conditions.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Biochemistry

Background:

  • Excessive reactive oxygen species (ROS) cause biomolecular damage, contributing to diseases like neurodegeneration and inflammation.
  • Antioxidants, such as Mitoquinone, can mitigate ROS-induced damage.
  • Nanozymes, nanomaterials with enzyme-like and antioxidant properties, are emerging as potential therapeutic agents.

Purpose of the Study:

  • To review nanozymes with inherent antioxidant activities.
  • To discuss strategies for modulating nanozyme catalytic activity.
  • To summarize nanozyme efficacy in treating ROS-related diseases.

Main Methods:

  • Literature review of nanozymes and their antioxidant properties.
  • Analysis of strategies for tuning nanozyme catalytic activity (size, shape, composition, environment).
  • Compilation of studies on nanozyme performance in treating ROS-induced pathologies.

Main Results:

  • Nanozymes exhibit diverse intrinsic antioxidant properties.
  • Catalytic activity of nanozymes can be modulated through physical and chemical strategies.
  • Nanozymes demonstrate therapeutic potential in various ROS-related disease models.

Conclusions:

  • Nanozymes represent a promising class of antioxidants for treating ROS-mediated diseases.
  • Modulating nanozyme characteristics is crucial for optimizing therapeutic outcomes.
  • Further research into nanozyme applications holds significant therapeutic promise.
Keywords:
ROS-related diseasesantioxidantenzyme-mimicnanozymesoxidative stress

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