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Updated: Aug 20, 2025

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
[Diagnosis of hypomimia in Parkinson's disease]
A A Khomchenkova1, S V Prokopenko1,2, V A Gurevich1,2
1Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
Objective:
A clinical approbation of a proprietary method for evaluation of the diagnostic value of computer video analysis of hypomimia in patients with Parkinson's disease (PD).
Material And Methods:
The study included 31 patients diagnosed with PD and 31 healthy people. The method consists in contactless recognition of 68 reference points on the face that are used to determine the movement of eyebrows, eyelids and the mouth during diagnostic tests: smiling, drawing of the letter "O", winking, eyebrow raising, frowning, and text reading.
Results:
Comparison of the results obtained with characteristics of healthy subjects has revealed statistically significant difference in the amplitude and speed of eyebrow, eyelid and mouth movement in PD patients.
Conclusion:
The method offers prospects for screening of patients with suspected PD and evaluation of therapy efficacy.
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