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Crown Ethers

Crown Ethers

Crown ethers are cyclic polyethers that contain multiple oxygen atoms, usually arranged in a regular pattern. The first crown ether was synthesized by Charles Pederson while working at DuPont in 1967. For this work, Pedersen was co-awarded the 1987 Nobel Prize in Chemistry. Crown ethers are named using the formula x-crown-y, where x is the total number of atoms in the ring and y is the number of ether oxygen atoms. The term 'crown' refers to the crown-like shape that these ether...

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Related Experiment Video

Updated: Aug 20, 2025

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Dendritic Quaternary-Encoded Oligourethanes for Data Encryption.

Qiangqiang Shi¹, Xin Zhou¹, Jie Xu¹

¹Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, China.

Angewandte Chemie (International Ed. in English)

|November 22, 2022

Summary

Sequence-defined digital polymers offer stable data storage. New dendritic oligourethanes provide high-strength encryption keys, preventing information leakage through unique mass spectrometry sequencing resistance.

Keywords:

Cascade Depolymerization Data Encryption Oligourethane Self-Immolative Sequence-Encoded

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Area of Science:

Polymer Chemistry
Data Security
Organic Synthesis

Background:

Sequence-defined digital polymers are explored for data storage due to their stability and precision.
Existing sequencing techniques pose risks of information leakage.
Need for advanced encryption methods in digital data storage.

Purpose of the Study:

To develop novel sequence-defined polymers for secure data encryption.
To address information leakage concerns associated with current sequencing technologies.
To create a robust encryption system using dendritic structures.

Main Methods:

Synthesis of dendritic quaternary-encoded oligourethanes with photoresponsive triggers, self-immolative backbones, and mass spectrometry tags.
Utilizing mass spectrometry (MS) and tandem MS/MS for sequencing analysis.
Analyzing fragmentation pathways of dendritic structures under MS/MS conditions.

Main Results:

Dendritic oligourethanes exhibit unique spatial conformations preventing standard MS/MS sequencing.
Fragmentation patterns of quaternary dendrimers can be converted into 2772-bit 2D matrices.
Achieved approximately 1.98×10^87 possible permutations for encryption keys.

Conclusions:

Developed a novel class of dendritic polymers for secure data encryption.
Demonstrated resistance to conventional sequencing methods, enhancing data security.
Established a high-capacity encryption system with a vast key space for reliable data protection.