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One-Dimensional Ferroelectric Nanoarrays with Wireless Switchable Static and Dynamic Electrical Stimulation for
Cairong Xiao1, Lei Fan2, Shiqi Zhou3
1School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510641, China.
Abstract:
Preventing local tumor recurrence and simultaneously improving bone-tissue regeneration are in great demand for osteosarcoma therapy. However, the current therapeutic implants fail to selectively suppress tumor growth and enhance osteogenesis, and antitumor therapy may compromise osseointegration of the bone implant. Here, based on the different responses of bone tumor cells and osteoblasts to different electric stimulations, we constructed ferroelectric BaTiO3 nanorod arrays (NBTO) on the surface of titanium implants with switchable dynamic and static electrical stimulation for selective bone-tumor therapy and bone tissue regeneration. Polarized NBTO (PNBTO) generated a sustained dynamic electrical stimulus in response to wireless ultrasonic irradiation ("switch-on"), which disrupted the orientation of the spindle filaments of the tumor cell, blocked the G2/M phase of mitosis, and ultimately led to tumor cell death, whereas it had almost no cytotoxic effect on normal bone cells. Under the switch-off state, PNBTO with a high surface potential provided static electrical stimulation, accelerating osteogenic differentiation of mesenchymal stem cells and enhancing the quality of bone regeneration both in vitro and in vivo. This study broadens the biomedical potential of electrical stimulation therapy and provides a comprehensive and clinically feasible strategy for the overall treatment and tissue regeneration in osteosarcoma.
Insights
This study introduces novel ferroelectric nanorod arrays on titanium implants for osteosarcoma treatment. These arrays selectively kill tumor cells with dynamic electrical stimulation and promote bone regeneration with static electrical stimulation.
Area of Science:
- Biomaterials Science
- Orthopedic Oncology
- Regenerative Medicine
Background:
- Osteosarcoma therapy requires implants that prevent tumor recurrence and enhance bone regeneration.
- Current implants struggle to selectively target tumor cells while promoting osteogenesis.
- Antitumor therapies can negatively impact bone implant osseointegration.
Purpose of the Study:
- To develop a switchable electrical stimulation strategy for selective bone-tumor therapy and bone tissue regeneration.
- To utilize ferroelectric barium titanate nanorod arrays (NBTO) on titanium implants.
- To leverage differential cellular responses to dynamic and static electrical stimuli.
Main Methods:
- Constructed ferroelectric BaTiO3 nanorod arrays (NBTO) on titanium implant surfaces.
- Applied wireless ultrasonic irradiation to induce dynamic electrical stimulation ('switch-on').
- Utilized static electrical stimulation in the 'switch-off' state.
Main Results:
- Dynamic stimulation disrupted tumor cell mitosis and induced cell death without harming normal bone cells.
- Static stimulation accelerated osteogenic differentiation of mesenchymal stem cells.
- Enhanced bone regeneration quality both in vitro and in vivo was observed.
Conclusions:
- Switchable electrical stimulation via NBTO offers a selective approach for osteosarcoma treatment.
- This strategy effectively inhibits tumor growth while promoting bone tissue regeneration.
- The findings present a comprehensive and clinically feasible approach for osteosarcoma management and bone repair.
