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Updated: Aug 20, 2025

Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Biatrial Volumetric Assessment by Non-ECG-Gated CT Pulmonary Angiography Correlated with Transthoracic

Deepa Gopalan1,2, Jan Riley3, Kai'En Leong4

  • 1Department of Physiology & Pharmacology, Karolinska Institute, 17177 Stockholm, Sweden.

Tomography (Ann Arbor, Mich.)
|November 22, 2022
PubMed

Insights

Normal biatrial volumes were established using computed tomography pulmonary angiography (CTPA). CTPA provides a reproducible method for atrial volumetric assessment, aiding cardiopulmonary evaluations.

Area of Science:

  • Cardiology
  • Radiology
  • Medical Imaging

Background:

  • Atrial size is a key predictor of cardiovascular mortality.
  • Normative values for biatrial volumes using non-ECG-gated CTPA are currently lacking.
  • CTPA is a common imaging modality for cardiopulmonary assessment.

Purpose of the Study:

  • To derive normal biatrial volumes using CTPA.
  • To compare CTPA-derived biatrial volumes with transthoracic echocardiography (TTE).
  • To assess the reproducibility of atrial volumetric assessment on CTPA.

Main Methods:

  • Manual and semiautomated segmentation were used on non-ECG-gated CTPA scans.
  • Thirty-five patients in sinus rhythm with normal diastolic function and no cardiovascular disease were included.
  • CTPA measurements were compared to TTE volumes using the area-length method.

Main Results:

  • Normal left atrial indexed volume (LAVi) was 27 ± 5 mL/m² and right atrial indexed volume (RAVi) was 20 ± 6 mL/m² by TTE.
  • Normal LAVi was 30 ± 8 mL/m² and RAVi was 29 ± 9 mL/m² by CTPA.
  • Bland-Altman analysis indicated TTE underestimated biatrial volumes compared to CTPA, with significant mean biases.

Conclusions:

  • Atrial volumetric assessment using CTPA is feasible, easy, and reproducible.
  • CTPA can provide valuable additional metrics for comprehensive cardiopulmonary assessment.
  • Established normative CTPA biatrial volumes can enhance diagnostic capabilities.

Keywords:
CT atrial sizeCT atrial volumesCT biatrial sizeCT biatrial volumesCT indexed atrial volumesCT planimetry

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