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Juvenile localized scleroderma: A single-centre experience from India.

Ankur Kumar Jindal1, Sanjeev Handa2, Sathish Kumar Loganathan1

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Early systemic corticosteroids combined with methotrexate show better outcomes for juvenile localized scleroderma (JLS) than methotrexate alone. This study highlights treatment responses in Indian JLS patients.

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Area of Science:

  • Pediatric Rheumatology
  • Dermatology
  • Autoimmune Diseases

Background:

  • Juvenile localized scleroderma (JLS) is a rare, chronic autoimmune condition affecting skin and underlying tissues.
  • This study presents the largest single-center cohort of JLS patients from India.

Purpose of the Study:

  • To analyze the clinical characteristics, laboratory findings, and management of JLS patients.
  • To identify factors predicting treatment response in JLS.

Main Methods:

  • Retrospective analysis of 84 JLS patients from pediatric dermatology and rheumatology clinics.
  • Data collected included clinical profile, investigations, and treatment modalities.

Main Results:

  • Linear scleroderma was the most common subtype (67.7%).
  • Extracutaneous manifestations (ECMs) occurred in 16.6% of patients, including arthritis and brain abnormalities.
  • Dexamethasone oral mini-pulse (OMP) and calcipotriol predicted good treatment response.

Conclusions:

  • Early combination therapy with systemic corticosteroids and methotrexate appears more effective than methotrexate alone for JLS.
  • Treatment strategies should consider individual patient profiles and potential ECMs.