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Updated: Aug 20, 2025

Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors
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Endodermal sinus tumor with pancreatic origin: A case report.

Muhammad Jawad Zahid1, Musarrat Hussain1, Muhammad Zeb1

  • 1General surgery department, Hayatabad Medical Complex, Peshawar, Pakistan.

International Journal of Surgery Case Reports
|November 22, 2022
PubMed
Summary
This summary is machine-generated.

This case report details an extremely rare endodermal sinus tumor in a young male

Keywords:
AFPCase reportEndodermal sinus tumorExtragonadal germ cell tumorPancreasPancreatic tumorchemotherapywhipple procedure

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Endodermal sinus tumors (ESTs) are rare malignant germ cell tumors (GCTs).
  • Primary pancreatic ESTs are exceptionally uncommon, posing diagnostic and therapeutic challenges.

Observation:

  • A 22-year-old male presented with a pancreatic mass, nausea, vomiting, and elevated alpha-fetoprotein (AFP) levels.
  • Initial tumor unresectability necessitated gastrojejunostomy for symptom relief.
  • Diagnosis confirmed as endodermal sinus tumor of pancreatic origin via biopsy and imaging.

Findings:

  • The patient received 4 cycles of BEP chemotherapy (bleomycin, etoposide, cisplatin).
  • A subsequent Whipple procedure successfully removed the residual pancreatic tumor.
  • This case highlights successful multimodal treatment for an aggressive malignancy.

Implications:

  • Increased awareness of rare extra-gonadal germ cell tumors is crucial for oncologists and surgeons.
  • Multidisciplinary approaches involving chemotherapy and surgical resection are vital for managing pancreatic ESTs.
  • Early diagnosis and tailored treatment strategies can improve outcomes for rare GCTs.