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Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

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3D-Printed Radiopaque Microdevices with Enhanced Mucoadhesive Geometry for Oral Drug Delivery.

Tien-Jen Chang1, Rolf Bech Kjeldsen1, Juliane Fjelrad Christfort1

  • 1The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, 2800, Denmark.

Advanced Healthcare Materials
|November 22, 2022
PubMed
Summary
This summary is machine-generated.

3D printed microcontainers with special shapes show improved gastrointestinal retention, enhancing oral drug delivery and bioavailability. This novel approach tracks microdevice behavior in vivo for better drug formulation design.

Keywords:
X-ray imaginggastrointestinal trackingmicrocontainersmicroscale 3D printingmucoadhesionstereolithography

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Oral drug delivery faces bioavailability challenges.
  • Current microdevice fabrication is limited to simple designs.
  • Advanced microdevices are needed to improve drug retention in the gastrointestinal tract.

Purpose of the Study:

  • To explore microscale stereolithography 3D printing for fabricating advanced oral drug delivery microdevices.
  • To design radiopaque microcontainers with enhanced mucoadhesive geometries.
  • To investigate the in vivo gastrointestinal retention of these 3D printed microdevices.

Main Methods:

  • Microscale stereolithography 3D printing was used to create radiopaque microcontainers with mucoadhesive features.
  • Ex vivo mucoadhesion force measurements were performed.
  • In vivo studies utilized X-ray imaging, computed tomography scanning, and cryogenic scanning electron microscopy.

Main Results:

  • Microcontainers with features like pillars and arrows demonstrated increased mucoadhesion compared to neutral designs.
  • In vivo imaging successfully traced the time-dependent gastrointestinal location of the microcontainers.
  • Cryogenic scanning electron microscopy provided insights into mucosal interactions and spatial dynamics.

Conclusions:

  • 3D printed microcontainers with specifically designed geometries can enhance gastrointestinal retention.
  • This study establishes a novel in vivo method to evaluate the impact of microdevice design on drug delivery.
  • The findings pave the way for improved oral drug delivery systems with enhanced bioavailability.