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Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
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Clinical and laboratory predictors for disease progression in patients with COVID-19: A multi-center cohort study

Shu-Min Lin1, Allen Chung-Cheng Huang1, Tzu-Hsuan Chiu1

  • 1Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Biomedical Journal
|November 22, 2022
PubMed

Insights

Predictors of severe COVID-19 include coronary arterial disease (CAD), cerebrovascular attack (CVA), low platelet count, and elevated C-reactive protein (CRP). These factors help identify patients at risk for disease progression.

Area of Science:

  • Infectious Diseases
  • Internal Medicine
  • Cardiology

Background:

  • Identifying predictors for coronavirus disease 2019 (COVID-19) progression is crucial for managing severe cases.
  • Early identification of at-risk patients can guide clinical interventions and resource allocation.

Purpose of the Study:

  • To identify clinical and laboratory predictors of in-hospital disease progression in COVID-19 patients.
  • To determine factors associated with increased severity and adverse outcomes in COVID-19.

Main Methods:

  • A cohort of 239 hospitalized COVID-19 patients was analyzed.
  • Demographic data, laboratory results, and clinical outcomes were collected and analyzed using multivariate logistic regression.

Main Results:

  • Coronary arterial disease (CAD), cerebrovascular attack (CVA), platelet count below the median, and C-reactive protein (CRP) levels above the median were independent predictors of COVID-19 progression.
  • Patients with disease progression showed lower lymphocyte counts and higher CRP levels compared to those without progression.

Conclusions:

  • Comorbidities like CAD and CVA, along with laboratory markers (low platelets, high CRP), are significant indicators of COVID-19 disease progression.
  • Persistent low lymphocyte counts and elevated CRP levels are characteristic of patients experiencing disease progression.
Abstract

Keywords:
COVID-19OutcomesProgression

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