Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Crossing Over01:30

Crossing Over

4.6K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
4.6K
Karyotyping01:17

Karyotyping

62.1K
Overview
62.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.

Biochemical and biophysical research communications·2026
Same author

Anticancer Therapeutic Potential of Mitochondria-Targeted Antioxidants Against N-Nitrosodiethylamine-Induced Hepatocarcinogenesis.

Cell biochemistry and function·2026
Same author

Molecular characterization of individuals with RASopathies: Spectrum of genetic variants in a large Indian cohort.

Journal of genetics·2026
Same author

High-dose cannabidiol for chronic neuropathic pain associated with spinal cord injury: a randomised clinical trial.

EClinicalMedicine·2026
Same author

Improving Oral Health After Spinal Cord Injury: A Scoping Review of Barriers, Facilitators, Current Interventions and Their Effectiveness.

Clinical and experimental dental research·2026
Same author

Safety and efficacy of intensive task-specific training in people with recent spinal cord injury: a phase 3, pragmatic, randomised, assessor-blinded, superiority trial.

The Lancet. Neurology·2026

Related Experiment Video

Updated: Aug 20, 2025

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K

Preimplantation Genetic Testing for Couples with Balanced Chromosomal Rearrangements.

Sachin Shetty1, Jiny Nair1, Jnapti Johnson1

  • 1Tattvagene Pvt. Ltd., Bangalore, India.

Journal of Reproduction & Infertility
|November 23, 2022
PubMed
Summary

Preimplantation genetic testing for structural chromosome rearrangements (PGT-SR) helps select balanced embryos in couples with chromosomal rearrangements, improving IVF success rates and reducing miscarriages. This method increases the chance of a healthy pregnancy.

Keywords:
AneuploidyBalanced chromosomal rearrangementsIn vitro fertilizationInversionPreimplantation genetic testingReciprocal translocationRecurrent miscarriagesRobertsonian translocation

More Related Videos

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.5K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.2K

Related Experiment Videos

Last Updated: Aug 20, 2025

FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.5K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.2K

Area of Science:

  • Genetics
  • Reproductive Medicine
  • Embryology

Background:

  • Chromosomal rearrangements are a significant cause of infertility and recurrent miscarriages.
  • Abnormal chromosome segregation during meiosis in carriers leads to unbalanced gametes.
  • Preimplantation genetic testing for structural chromosome rearrangements (PGT-SR) aids in selecting chromosomally normal embryos for IVF.

Purpose of the Study:

  • To evaluate the outcomes of PGT-SR in patients with balanced chromosomal rearrangements.
  • To assess the clinical pregnancy and live birth rates following PGT-SR and IVF.

Main Methods:

  • Retrospective analysis of infertile couples undergoing PGT-SR.
  • Study conducted at a single fertility center from January 2016 to December 2019.
  • Analysis included embryos from 22 couples with balanced translocations or inversions.

Main Results:

  • PGT-SR was performed on 87 embryos; 34.5% were normal or balanced.
  • 18 couples underwent embryo transfer with 30 chromosomally normal/balanced embryos.
  • The live birth rate per embryo transfer was 66.6%.

Conclusions:

  • PGT-SR is effective in identifying and selecting normal or balanced embryos for IVF.
  • This technology can significantly reduce miscarriage rates in couples with chromosomal rearrangements.
  • PGT-SR improves pregnancy outcomes for individuals with balanced chromosomal abnormalities.