Plant Derived Immunomodulators; A Critical Review.

Area of Science:

• Immunology and Natural Product Chemistry
• Focuses on the intersection of traditional medicine and modern therapeutic strategies.

Background:

• Immunomodulation, the concept of altering immune responses, is crucial for treating autoimmune diseases, viral infections, and cancers.
• Elevated expression of specific immune-related genes (immunocytokines) is a hallmark of these conditions.
• Phytomedicines (plant-based medicines) are increasingly recognized for their immunostimulant and immunosuppressant properties.

Purpose of the Study:

• To review traditional medicinal plants and their constituents with established immunomodulating properties.
• To highlight the mechanisms of action, including effects on autophagy and drug adjuvanticity.

Main Methods:

• Literature review of traditional plants and phytochemicals with immunomodulatory effects.
• Analysis of scientific evidence supporting their use in treating immune-related diseases.
• Exploration of proposed mechanisms of action at the molecular level.

Main Results:

• Identified various plant-derived phytochemicals (flavonoids, terpenoids, polysaccharides, etc.) exhibiting immunomodulating activities.
• Documented traditional uses of these plants in managing a range of ailments.
• Highlighted the role of autophagy and adjuvanticity in the therapeutic effects of these compounds.

Conclusions:

• Traditional plants and their phytochemical constituents represent a valuable resource for developing novel immunomodulatory therapies.
• Further research into their mechanisms of action can unlock their full therapeutic potential for immune-related disorders.
• Phytomedicines offer a promising avenue for both prophylactic treatment and management of complex diseases.