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Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application
Arezo Azari1, Ali Golchin2,3, Maryam Mahmoodinia Maymand4
1Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Advanced Pharmaceutical Bulletin
|November 23, 2022
Summary
Polycaprolactone (PCL) electrospun nanofibers offer unique properties for regenerative medicine. This review highlights their advancements in tissue engineering and drug delivery, showcasing significant progress in mechanobiological performance.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Regenerative Medicine
Background:
- Polycaprolactone (PCL) is a versatile biomaterial known for its mechanical properties, miscibility, and biodegradability.
- Electrospinning is an efficient technique for fabricating nanofibrous structures from PCL.
- These PCL-based nanofibrous composites serve as scaffolds in various biomedical applications.
Purpose of the Study:
- To review the mechanochemical properties and biological performance of PCL electrospun fibrous structures.
- To discuss the current progress and future prospects of electrospun PCL nanofibers in biomedical applications.
- To highlight the significance of PCL electrospun nanofibers in regenerative medicine.
Main Methods:
- Literature review of studies on polycaprolactone (PCL) electrospun nanofibers.
- Compilation and analysis of data on mechanochemical properties.
- Evaluation of biological performance in biomedical applications.
Main Results:
- Electrospun PCL nanofibers exhibit desirable properties for scaffold fabrication.
- These structures are effectively used in stem cell research, tissue engineering, wound dressing, and drug delivery systems.
- Significant advancements have been observed in the mechanobiological properties of PCL-based electrospun composites.
Conclusions:
- Electrospun PCL nanofibers are gaining substantial attention in regenerative medicine.
- These materials demonstrate notable development in mechanobiological properties, crucial for biomedical strategies.
- The review underscores the potential of PCL electrospun nanofibers for future biomedical innovations.
