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Biological and technical challenges for implementation of yeast-based biosensors
Ehtisham Wahid1, Ohiemi Benjamin Ocheja2, Enrico Marsili3
1DEI - Department of Electrical and Information Engineering - Politecnico di Bari, Bari, Italy.
Microbial Biotechnology
|November 23, 2022
Summary
Yeast-based biosensors offer robust, sensitive analyte detection for various applications. While promising, most are in early development, requiring advanced tools and electrochemical integration for real-world use.
Area of Science:
- Microbiology
- Biotechnology
- Analytical Chemistry
Background:
- Biosensors provide cost-effective analytical alternatives for biomedical, industrial, and environmental fields.
- Genetically engineered whole microorganism biosensors offer high sensitivity and specificity.
- Yeast-based biosensors combine microbial benefits with eukaryotic advantages like stability and robustness.
Purpose of the Study:
- To review recently developed yeast-based biosensors.
- To highlight their biological and technical characteristics.
- To assess their current development status (laboratory or prototype).
Main Methods:
- Literature review of recently reported yeast-based biosensors.
- Analysis of biological features, technical aspects, and development stage.
- Discussion of challenges and potential solutions for real-world application.
Main Results:
- Most yeast-based biosensors are in the early laboratory development stage.
- Few prototypes have been tested for actual applications.
- Key challenges include integrating advanced molecular tools and electrochemical setups.
Conclusions:
- Yeast-based biosensors show significant potential but require further development.
- Addressing challenges in advanced tools, bioprospecting, and electrochemical integration is crucial.
- Overcoming bottlenecks will promote the real-world application of these biosensors.
