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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Persistent Asthma Is Associated With Carotid Plaque in MESA
Matthew C Tattersall1, Alison S Dasiewicz2, Robyn L McClelland3
1Department of Medicine, Division of Cardiovascular Medicine University of Wisconsin School of Medicine and Public Health Madison WI.
Journal of the American Heart Association
|November 23, 2022
Summary
Persistent asthma is linked to higher carotid plaque burden, a key indicator of cardiovascular disease risk. This association persists even after accounting for inflammatory markers, suggesting a complex relationship.
Area of Science:
- Cardiology
- Pulmonology
- Inflammation Research
Background:
- Asthma and atherosclerotic cardiovascular disease share inflammatory pathways.
- Persistent asthma may be linked to increased carotid plaque burden.
Purpose of the Study:
- To investigate the association between asthma subtypes and carotid plaque burden.
- To determine if inflammation mediates the relationship between asthma and atherosclerosis.
Main Methods:
- Analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
- Carotid ultrasound to assess total plaque score (TPS).
- Multivariable regression modeling to evaluate asthma subtype and plaque association.
Main Results:
- Persistent asthma was associated with significantly higher carotid plaque presence and TPS.
- Participants with persistent asthma showed elevated interleukin-6 levels.
- The association between persistent asthma and plaque burden remained significant after adjusting for inflammatory markers.
Conclusions:
- Persistent asthma is linked to increased carotid plaque burden and elevated inflammatory biomarkers.
- The heightened atherosclerotic cardiovascular disease risk in persistent asthma appears multifactorial.
- Inflammatory biomarkers do not fully explain the observed association.
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