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Research progress on the circRNA‑mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)

Dandan Meng1, Ruixue Jia1, Shun Yuan1

  • 1Department of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, P.R. China.

Oncology Reports
|November 23, 2022
PubMed

Insights

Circular RNAs (circRNAs) regulate tumor angiogenesis by acting as microRNA sponges, impacting tumor growth and metastasis. These findings highlight circRNAs as potential diagnostic markers and therapeutic targets for anti-angiogenic cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Tumors pose a significant global health threat, with angiogenesis being crucial for their development and spread.
  • Circular RNAs (circRNAs) are emerging as key regulators in various biological processes, including cancer.

Approach:

  • This review summarizes the role of circRNAs in regulating tumor angiogenesis via competing endogenous RNA (ceRNA) mechanisms.
  • It focuses on how circRNAs influence vascular endothelial growth factor (VEGF)-related pathways.

Key Points:

  • CircRNAs act as microRNA sponges, modulating pathways essential for tumor angiogenesis.
  • Their involvement spans tumor growth, invasion, and proliferation.
  • Specific examples of circRNAs regulating tumor angiogenesis in diverse systems are discussed.

Conclusions:

  • CircRNAs demonstrate significant potential as diagnostic biomarkers for tumors.
  • They also represent promising targets for novel anti-angiogenic therapies.
  • Further research into circRNAs is warranted for clinical applications in oncology.
Keywords:
circular RNAcompeting endogenous RNAsmicroRNAtumor angiogenesisvascular endothelial growth factor

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