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Updated: Aug 20, 2025
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Central nervous system involvement by mantle cell lymphoma.
Nicole McLaughlin1, Yucai Wang2, Thomas Witzig2
1Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Leukemia & Lymphoma
|November 23, 2022
Summary
Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is rare and leads to poor outcomes. Patients with CNS MCL had significantly shorter overall survival compared to those without CNS involvement.
Area of Science:
- Hematology
- Oncology
- Neurology
Background:
- Mantle cell lymphoma (MCL) can rarely involve the central nervous system (CNS).
- CNS involvement in MCL presents limited therapeutic strategies.
- Outcomes for MCL patients with CNS disease are poorly defined.
Purpose of the Study:
- To compare outcomes of MCL patients with CNS involvement versus those without.
- To identify prognostic factors associated with CNS involvement in MCL.
Main Methods:
- Retrospective analysis of 36 MCL patients with CNS involvement.
- Comparison with 72 matched MCL control patients without CNS involvement.
- Analysis of overall survival (OS) and progression-free survival (PFS) from diagnosis and CNS involvement.
Main Results:
- Median OS from MCL diagnosis was significantly shorter for CNS MCL patients (50.3 months) compared to controls (97.1 months).
- Median OS from CNS involvement was only 4.7 months.
- Advanced stage, blastoid variant, elevated LDH, and elevated Ki67 at diagnosis were more frequent in the CNS MCL cohort.
Conclusions:
- CNS involvement in MCL is associated with dismal prognosis and significantly reduced survival.
- Early identification of prognostic factors may aid in managing CNS MCL.
- Further research into targeted therapies for CNS MCL is warranted.
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