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Updated: Aug 20, 2025

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
Nanoparticle-based delivery of nitric oxide for therapeutic applications
Okhil K Nag1, Kwahun Lee1,2, Michael H Stewart3
1Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Code 6900, 4555 Overlook Ave. SW, Washington, DC, 20375, USA.
Abstract:
Nitric oxide (NO), a low molecular weight signaling molecule, plays critical roles in both cellular health and disease. There is continued interest in new modalities for the controlled therapeutic delivery of NO to cells and tissues. The physicochemical properties of NO (including its short half-life and on-demand synthesis at the point of function), however, pose considerable challenges for its specific and efficient delivery. Recently, a number of nanoparticle (NP)-based systems are described that address some of these issues by taking advantage of the unique attributes of the NP carrier to effect efficient NO delivery. This review highlights the progress that has been made over the past 5 years in the use of various constructs for the therapeutic delivery of NO.
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