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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Micro- and nano-devices for electrochemical sensing.

Federica Mariani¹, Isacco Gualandi², Wolfgang Schuhmann³

¹Dipartimento Di Chimica Industriale "Toso Montanari", Università Di Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy. federica.mariani8@unibo.it.

Mikrochimica Acta

|November 23, 2022

Summary

Electrode miniaturization has advanced electrochemical sensing for biological event detection. This review covers micro- and nano-electrochemical sensor trends and applications, highlighting future research needs.

Keywords:

Electrochemical sensor Microelectrode Miniaturization Nanoelectrode Transistor

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Area of Science:

Electrochemistry
Materials Science
Biotechnology

Background:

Electrode miniaturization has significantly impacted electrochemical sensing.
This has enabled high-resolution probing of biological events and integration with microfluidics.
Current micrometric and nanometric sensing systems show varying maturity levels.

Purpose of the Study:

To present current trends in micro-/nano-electrochemical sensor design.
To review cutting-edge applications reported in the last 10 years.
To identify areas for improvement in electrochemical sensing strategies.

Main Methods:

Categorization of micro- and nanosensors based on transduction mechanisms (amperometric, impedimetric, potentiometric, transistor-based).
Review of recent advancements and applications in electrochemical sensing.
Analysis of current technological challenges and future demands.

Main Results:

Micro-/nano-electrochemical sensors offer advanced capabilities for biological event probing.
Key applications include lab-on-a-chip devices, multiplexed sensing, brain chemistry, and cell monitoring.
Significant progress has been made, but further improvements are needed for demanding applications.

Conclusions:

Micro- and nano-electrochemical sensors are crucial for high-resolution biological analysis.
Continued research is essential to address limitations and meet the demands of advanced sensing fields.
This review provides a guide to detection strategies and highlights future research directions.