Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
K A Jones1,2, C A Paterson3,4, S Ray5
1Department of Nuclear Cardiology, Glasgow Royal Infirmary, Glasgow, UK. kirsty.jones.2@glasgow.ac.uk.
Background:
Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters.
Methods:
A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated.
Results:
An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups.
Conclusions:
A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.
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