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Predictive value of oxidative, antioxidative, and inflammatory status for left ventricular systolic recovery after
Fatih Aksoy1, Hasan Aydin Baş2, Ali Bağcı1
1Suleyman Demirel University, Medical School, Department of Cardiology - Isparta, Turkey.
Objective:
This study aimed to evaluate the association between left ventricular ejection fraction recovery and the total oxidant status, total antioxidant capacity, and high-sensitivity C-reactive protein levels.
Methods:
A total of 264 ST-elevation myocardial infarction patients were classified into two groups according to baseline and 6-month follow-up left ventricular systolic function: reduced and recovery systolic function. Predictors of the recovery of left ventricular ejection fraction were determined by multivariate regression analyses.
Results:
Multivariable analysis indicated that oxidative status index, baseline left ventricular ejection fraction and peak creatine-kinase myocardial bundle level, and high-sensitivity C-reactive protein were independently associated with the decreased of left ventricular ejection fraction at 6-month follow-up.
Conclusion:
Oxidative stress and inflammation parameters were detrimental to the recovery of left ventricular ejection fraction in patients with ST-elevation myocardial infarction.
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