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Mediterranean diet for the prevention of gestational diabetes: a meta-analysis of randomized controlled trials
Introduction:
It is elusive that whether that Mediterranean diet helps prevent gestational diabetes. This meta-analysis aims to study the efficacy of Mediterranean diet for gestational diabetes mellitus.
Methods:
We have systematically searched PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and included randomized controlled trials (RCTs) that reported the effect of Mediterranean diet on gestational diabetes.
Results:
We included five eligible RCTs in this meta-analysis. Compared with control intervention for pregnant women, Mediterranean diet could substantially decrease the incidence of gestational diabetes mellitus (OR = 0.64; 95% CI = 0.51 to 0.79; p < 0.0001), HOMA-IR (MD = -0.29; 95% CI = -0.50 to -0.09; p = 0.004), insulin treatment (OR = 0.39; 95% CI = 0.22 to 0.68; p = 0.0009) and gestational weight gain (MD = -0.74; 95% CI = -1.21 to -0.28; p = 0.002), but demonstrated no obvious impact on the admission of neonatal unit (OR = 0.75; 95% CI = 0.47 to 1.20; p = 0.24).
Conclusions:
Mediterranean diet can effectively prevent gestational diabetes mellitus.
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